TRANSLATIONAL PHYSIOLOGY Gain of allelic gene expression for IGF-II occurs frequently in Barrett’s esophagus
نویسندگان
چکیده
Linda A. Feagins, Nathan Susnow, Hui Ying Zhang, Stephanie Pearson, Charles Owen, William F. Schmalstieg, Lance S. Terada, Stuart J. Spechler, Ruben D. Ramirez, and Rhonda F. Souza Department of Medicine, Dallas Veterans Affairs Medical Center and University of Texas Southwestern Medical School, Dallas; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical School, Dallas; and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas
منابع مشابه
Gain of allelic gene expression for IGF-II occurs frequently in Barrett's esophagus.
The IGF-II gene normally exhibits genomic imprinting, a DNA modification that allows the expression of only one of the two inherited alleles. With loss of imprinting, there is a gain of allelic gene expression (GOAGE) due to IGF-II being expressed by both alleles. GOAGE for IGF-II has been demonstrated in a number of malignancies and in normal epithelia surrounding malignancies, but not in epit...
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تاریخ انتشار 2006